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Anti-NRDP1 Rabbit pAb (100 μl)
| Reactivity: | M,R & H,R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | E3 ubiquitin-protein ligase NRDP1 |
Synonyms: | FLRF, NRDP1, ring finger protein 41, RNF41, SBBI03 |
Immunogen: | Recombinant protein corresponding to Mouse NRDP1 |
Uniprot ID: | Q8BH75 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm, Nucleus |
Predicted MW. / Observed MW. | 36 kDa / 36 kDa |
Product Usage Information
WB | Mouse, Rat | 1: 300-1: 500 | brain, testis |
IHC/IF | Human, Rat | 1: 1000-1: 3000 | colon, ovarian cancer |
Background
Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88 (By similarity). Negatively regulates MYD88-dependent production of proinflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus. Promotes also activation of TBK1 and IRF3 . Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors.
Images
| Western blot analysis of RNF41 (GB114518) at dilution of 1: 500 |
| Immunohistochemistry of paraffin embedded human colon using RNF41 (GB114518) at dilution of 1: 1000 |
| Immunofluorescence of paraffin embedded human ovarian cancer using RNF41 (GB114518) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
