Your shopping cart is empty!
Anti-Notch1 Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Notch1 rabbit polyclonal antibody |
Gene Name: | Neurogenic locus notch homolog protein 1 |
Synonyms: | Notch 1, hN1, Translocation-associated notch protein TAN-1, Notch 1 extracellular truncation, NEXT, Notch 1 intracellular domain, NICD, TAN1, 9930111A19Rik, AOVD1, AOS5 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Human Notch1 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 273 kDa |
Observed MW. | 120 kDa |
Uniprot ID: | P46531, Q01705, Q07008 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Human, Mouse, Rat | 1: 400-1: 800 | brain, liver, cortex |
Background
NOTCH1, also named as TAN1, belongs to the NOTCH family. NOTCH1 functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. NOTCH1 affects the implementation of differentiation, proliferation and apoptotic programs. It may be important for normal lymphocyte function. In altered form, may contribute to transformation or progression in some T-cell neoplasms. NOTCH1 is involved in the maturation of both CD4+ and CD8+ cells in the thymus. May be important for follicular differentiation and possibly cell fate selection within the follicle.
Images
| Western blot analysis of Notch1 (GB111690) at dilution of 1: 400 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
