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Anti-Nurr1 Rabbit pAb (100 μl)
| Reactivity: | H,M,R & H,M & H,M |
| Applications: | WB & IHC & IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Nurr1 rabbit polyclonal |
Gene Name: | Nuclear receptor subfamily 4 group A member 2 |
Synonyms: | NUR-related factor 1, Orphan nuclear receptor NURR1, Nr4a2, Nurr1 |
Immunogen: | Recombinant protein corresponding to Mouse Nurr1 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | |
Predicted MW. | 67 kDa |
Observed MW. | 67 kDa |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human, Mouse, Rat | 1: 500-1: 800 | brain |
IHC | Human, Mouse | 1: 200-1: 800 | kidney cancer, breast cancer, tonsil, thyroid, brain, spleen |
IF | Human, Mouse | 1: 200-1: 800 | brain |
Background
NR4A2 belongs to the orphan nuclear receptor (NR) family referred to as NR4A family, which have been implicated in cell cycle regulation, apoptosis, inflammation, metabolism and more recently in carcinogenesis . NR4A2 also has a role in the expression of several proteins that are necessary for the synthesis and regulation of dopamine (DA), such as tyrosine hidroxilase, dopamine transporter, vesicular monoamine transporter 2 and cRET [PMID:22294735]. Act as a transcriptional regulator, NR4A2 is essential for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development.
Images
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Western blot analysis of Nurr1 (GB111267) at dilution of 1: 800 |
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Immunohistochemistry analysis of paraffin-embedded human kidney cancer using Nurr1 (GB111267) at dilution of 1: 800 |
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Immunohistochemistry analysis of paraffin-embedded human breast cancer using Nurr1 (GB111267) at dilution of 1: 200 |
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Immunohistochemistry analysis of paraffin-embedded human tonsil using Nurr1 (GB111267) at dilution of 1: 400 |
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Immunohistochemistry analysis of paraffin-embedded human thyroid using Nurr1 (GB111267) at dilution of 1: 200 |
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Immunohistochemistry analysis of paraffin-embedded mouse brain using Nurr1 (GB111267) at dilution of 1: 800 |
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Immunohistochemistry analysis of paraffin-embedded mouse spleen using Nurr1 (GB111267) at dilution of 1: 200 |
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Immunofluorescent analysis of paraformaldehyde-fixed mouse brain using Nurr1 (GB111267) at dilution of 1: 400 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
