Your shopping cart is empty!
| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | P35 rabbit polyclonal antibody |
Gene Name: | Cyclin-dependent kinase 5 activator 1 |
Synonyms: | CDK5 activator 1, Cyclin-dependent kinase 5 regulatory subunit 1, TPKII regulatory subunit, Tau protein kinase II 23 kDa subunit, Cdk5r1, CDK5P35, Neuronal CDK5 activator |
Immunogen: | Recombinant protein corresponding to Mouse P35 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 34 kDa |
Observed MW. | 35 kDa |
Uniprot ID: | P61809, P61810 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Mouse, Rat | 1: 500-1: 1000 | hippocampus, brain, spinal cord, cerebellum |
Background
Cyclin dependent kinase-5 (Cdk5), is an atypical but essential member of the Cdk family of proline-directed serine/threonine kinases. CDK5R1 encodes p35, a specific activator of the serine/threonine kinase CDK5, which plays a central role in neuronal migration and differentiation during central nervous system development. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form.The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location.
Images
|
Western blot analysis of P35 (GB111614) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
