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Anti-PAICS/PAIS Rabbit pAb (100 μl)
| Reactivity: | H |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | PAICS/PAIS rabbit polyclonal antibody |
Gene Name: | Multifunctional protein ADE2 |
Synonyms: | ADE2, ADE2H1, AIR carboxylase, AIRC, PAICS, PAIS, SAICAR synthetase, Phosphoribosylaminoimidazole carboxylase, Multifunctional protein ADE2H1, synthetase |
Immunogen: | Recombinant protein corresponding to Mouse PAICS/PAIS |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 47 kDa |
Observed MW. | 47 kDa |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Human | 1: 1000-1: 3000 | HeLa, HepG2, Jurkat, Raji, K562, U-251MG |
Background
PAICS is also named as ADE2(Multifunctional protein), AIRC, PAIS. It is an important bifunctional enzyme in de novo purine biosynthesis in vertebrate with both 5-aminoimidazole ribonucleotide carboxylase (AIRc) and 4-(N-succinylcarboxamide)-5-aminoimidazole ribonucleotide synthetase (SAICARs) activities. It becomes an attractive target for rational anticancer drug design, since rapidly dividing cancer cells rely heavily on the purine de novo pathway for synthesis of adenine and guanine, whereas normal cells favor the salvage pathway.
Images
 | Western blot analysis of PAICS (GB113869) at dilution of 1: 3000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
