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Anti-PARK7/DJ1 Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | PARK7/DJ1 rabbit polyclonal antibody |
Gene Name: | Protein/nucleic acid deglycase DJ-1 |
Synonyms: | PARK7, DJ-1, DJ1, HEL-S-67p, Parkinsonism associated deglycase, GATD2 |
Immunogen: | Recombinant protein corresponding to Mouse PARK7 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 20 kDa |
Observed MW. | 24 kDa |
Uniprot ID: | Q99LX0, Q99497, O88767 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human, Mouse, Rat | 1: 500-1: 1000 | brain, liver, kidney |
Background
Protein deglycase DJ-1, also known as Parkinson disease protein 7, is a protein which in humans is encoded by the PARK7 gene. Under an oxidative condition, protein deglycase DJ-1 inhibits the aggregation of α-synuclein via its chaperone activity, thus functions as a redox-sensitive chaperone and as a sensor for oxidative stress. Accordingly, DJ-1 apparently protects neurons against oxidative stress and cell death. In parallel, Protein DJ-1 acts as a positive regulator of androgen receptor-dependent transcription. Pyrroloquinoline quinone (PQQ) has been shown to reduce the self-oxidation of the DJ-1 protein, an early step in the onset of some forms of Parkinson's disease. Functional DJ-1 protein has been shown to bind metals and protect against metal-induced cytotoxicity from copper and mercury.
Images
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Western blot analysis of DJ-1 (GB11597) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
