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| Reactivity: | H |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | PD1 rabbit polyclonal |
Gene Name: | Programmed cell death protein 1 |
Synonyms: | Protein PD-1, mPD-1, CD279, Pdcd1, Pd1, SLEB2, Systemic lupus erythematosus susceptibility 2, hSLE1 |
Immunogen: | Recombinant protein corresponding to Human PD1 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC/IF | Human | 1: 500-1: 1000 | lung, tonsil |
Background
Programmed cell death 1 (PD-1, also known as CD279) is an immunoinhibitory receptor that belongs to the CD28/CTLA-4 subfamily of the Ig superfamily. It is a 288 amino acid (aa) type I transmembrane protein composed of one Ig superfamily domain, a stalk, a transmembrane domain, and an intracellular domain containing an immunoreceptor tyrosine-based inhibitory motif (ITIM) as well as an immunoreceptor tyrosine-based switch motif (ITSM) . PD-1 is expressed during thymic development and is induced in a variety of hematopoietic cells in the periphery by antigen receptor signaling and cytokines.
Images
| Immunohistochemistry analysis of paraffin-embedded human lung using PD1 (GB113744) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin-embedded human tonsil using PD1 (GB113744) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
