Your shopping cart is empty!
Anti-PDE1C/PDE1 Rabbit pAb (100 μl)
| Reactivity: | H,R & H,R & M |
| Applications: | WB & IHC/IF & ICC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C |
Synonyms: | Cam PDE 1C, hCam 3, Hcam3, PDE1C |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse PDE1C/PDE1 |
Uniprot ID: | Q64338 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Lysosome |
Predicted MW. / Observed MW. | 80 kDa / 59 kDa |
Product Usage Information
WB | Human, Rat | 1: 3000-1: 5000 | brain |
IHC/IF | Human, Rat | 1: 800-1: 2400 | colon cancer, kidney, liver, pancreas |
ICC/IF | Mouse | 1: 100-1: 400 | NIH-3T3 |
Background
Calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual-specificity for cAMP and cGMP, which are key regulators of many important physiological processes. Exhibits high affinity for both cAMP and cGMP. Modulates the amplitude and duration of the cAMP signal in sensory cilia in response to odorant stimulation, hence contributing to the generation of action potentials. Regulates smooth muscle cell proliferation. Regulates the stability of growth factor receptors, including PDGFRB (Probable).
Images
| Western blot analysis of PDE1C (GB114930) at dilution of 1: 3000 |
| Immunohistochemistry of paraffin embedded human colon cancer using PDE1C (GB114930) at dilution of 1: 800 |
| Immunohistochemistry of paraffin embedded human kidney using PDE1C (GB114930) at dilution of 1: 800 |
| Immunohistochemistry of paraffin embedded rat liver using PDE1C (GB114930) at dilution of 1: 800 |
| Immunohistochemistry of paraffin embedded rat pancreas using PDE1C (GB114930) at dilution of 1: 800 |
| Immunocytochemistry analysis of 4% paraformaldehyde-fixed NIH-3T3 cells using PDE1C (GB114930) at dilution of 1: 200 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
