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| Reactivity: | H,M |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Gamma-secretase subunit PEN-2 |
Synonyms: | MDS033, MSTP064 , PEN 2, psenen, PSEN2, Presenilin Enhancer 2 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse PEN2 |
Uniprot ID: | Q9CQR7 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 12 kDa / 15 kDa |
Product Usage Information
WB | Human, Mouse | 1: 500-1: 1000 | spleen |
Background
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (Probable). PSENEN modulates both endoproteolysis of presenilin and gamma-secretase activity.
Images
| Western blot analysis of PSENEN (GB114872) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
