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Anti-PSMD14 Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | PSMD14 rabbit polyclonal antibody |
Gene Name: | 26S proteasome non-ATPase regulatory subunit 14 |
Synonyms: | 26S proteasome regulatory subunit RPN11, MAD1, Psmd14, Pad1, Testis tissue sperm binding protein Li 69n |
Immunogen: | Recombinant protein corresponding to Mouse PSMD14 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 35 kDa |
Observed MW. | 35 kDa |
Uniprot ID: | O00487, O35593 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Human, Mouse, Rat | 1: 500-1: 1000 | HeLa, 293T, HepG2, A-431, MCF-7, K562, NIH/3T3, Jurkat, HT-29 |
Background
The PSMD14 (POH1, also known as Rpn11/MPR1/S13/CepP1) protein is a metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitin chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. PSMD14 is highly expressed in heart and skeletal muscle. In carcinoma cell lines. down-regulation of PSMD14 by siRNA transfection had a considerable impact on cell viability causing cell arrest in the G0-G1 phase, ultimately leading to senescence.
Images
| Western blot analysis of PSMD14 (GB111781) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
