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Anti-Perforin Rabbit pAb (100 μl)
| Reactivity: | H,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Perforin rabbit polyclonal antibody |
Gene Name: | Perforin-1 |
Synonyms: | P1, Cytolysin, Lymphocyte pore-forming protein, PFP, PRF1, FLH2, HPLH2, MGC65093, Perforin 1, Perforin 1 precursor, Perforin 1 preforming protein, PGFL, PIGF, PIGF-2, PLGF, SHGC-10760 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Human Perforin |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 61 kDa |
Observed MW. | 70 kDa |
Uniprot ID: | P14222, P35763 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human, Rat | 1: 500-1: 1000 | thymus, spleen, lung |
Background
Perforin 1 is one of the major cytolytic proteins of cytolytic granules. It is known to be a crucial effector molecule in cytolytic T lymphocyte and natural killer cell-mediated cytotoxicity. This protein has structural and functional similarities to complement component C9. Like C9, this protein creates transmembrane tubules and is capable of lysing nonspecifically a variety of target cells. Defects in PRF1 are the cause of familial hemophagocytic lymphohistiocytosis type 2 (FHL2), a rare and lethal autosomal recessive disorder of early childhood，which is characterized by immune dysregulation with hypercytokinemia and defective natural killer cell function. Alternative splicing results in multiple transcript variants encoding the same protein.
Images
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Western blot analysis of Perforin (GB11943) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
