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Anti-Phospho-JNK (Thr183/Tyr185) Mouse mAb (100 μl)
| Reactivity: | H & H |
| Applications: | WB & IHC/IF |
| Host Species: | Mouse |
| Clonality: | Monoclonal |
| Gene Name: | Mitogen-activated protein kinase 8/9/10 |
Synonyms: | JNK1 + JNK2 + JNK3, JNK1/2/3, JNK1+2+3, MAPK8, MAPK9, MAPK10, c Jun N terminal kinase 1, c Jun N terminal kinase 2, c Jun N terminal kinase 3, P-JNK |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Human JNK(T183/Y185) |
Uniprot ID: | P45983/P45984/P53779 |
Isotype: | IgG2b,κ |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm, Nucleus |
Predicted MW. / Observed MW. | 46/54 kDa /46/54 kDa |
Product Usage Information
WB | Human | 1: 500-1: 1000 | HT-29 |
IHC/IF | Human | 1: 500-1: 1000 | ovarian cancer, esophageal cancer, colon cancer, colon |
Background
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases.
Images
| Western blot analysis of P-JNK (GB12018) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin embedded human ovarian cancer using P-JNK (GB12018) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin embedded human esophageal cancer using P-JNK (GB12018) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin embedded human colon cancer using P-JNK (GB12018) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin embedded human colon using P-JNK (GB12018) at dilution of 1: 2000 |
| Immunohistochemistry analysis of paraffin embedded human colon using P-JNK (GB12018) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
