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Anti-Phospho-Tau (T231) Rabbit pAb (100 μl)
| Reactivity: | M,R & M,R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Microtubule-associated protein tau |
Synonyms: | Neurofibrillary tangle protein, Paired helical filament-tau, PHF-tau, MAPT, MAPTL, MTBT1, TAU, P-TAU |
Immunogen: | KLH conjugated Synthetic phosphopeptide corresponding to Human Tau (T231) |
Uniprot ID: | P10636-8 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm, Cytoskeleton, Secreted, Cell membrane, Cell projection |
Predicted MW. / Observed MW. | 79 kDa / 50-80 kDa |
Product Usage Information
WB | Mouse, Rat | 1: 500-1: 1000 | brain |
IHC/IF | Mouse, Rat | 1: 500-1: 1000 | alzheimer disease brain, brain |
Background
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity .Suggesting that tau functions as a linker protein between both .Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome.
Images
| Western blot analysis of Phospho-Tau (T231) (GB114488) at dilution of 1: 500 |
| Western blot analysis of Phospho-Tau (T231) (GB114488) at dilution of 1: 500 The figure above was untreated, the figure bleow was treated with lambda phosphatase |
| Immunohistochemistry analysis of paraffin embedded mouse Alzheimer disease brain using Phospho-Tau (T231) (GB114488) at dilution of 1: 500 The figure left was treated with non-phospho-blocking peptide, the figure right was treated with phospho-blocking peptide |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
