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| Product Category: | Human Adenovirus Type5 (dE1/E3) expressing Breast Cancer 1, Early Onset (BRCA1) under CMV promoter. |
| Description: | Breast Cancer 1, Early Onset, pre-made adenovirus, ready to ship and ready to use format. |
| Gene: | Breast Cancer 1, Early Onset |
| NCBI Acc. #: | NM_007294 |
| Gene ID: | 672 |
| GI Number: | 6552298 |
| Fusion Tag: | No |
| Promoter: | CMV |
| Titer: | 1×1010~1×1011 PFU/ml |
| Storage Buffer: | DMEM with 2.5% BSA, 2.5% glycerol |
| Background: | This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. |
| Storage: | -80°C |
| Documents: | Please contact us to request the manual |
