Adenovirus DYRK2 (200 μl)

Product Category:

Human Adenovirus Type5 (dE1/E3) expressing Dual-specificity Tyrosine-(Y)-phosphorylation Regulated Kinase 2 (DYRK2).

Description:

Dual-specificity Tyrosine-(Y)-phosphorylation Regulated Kinase 2, pre-made adenovirus, ready to ship and ready to use format.

Gene Name:

Dual-specificity Tyrosine-(Y)-phosphorylation Regulated Kinase 2

ACCN:

BC006375

Gene ID:

8445

GI Number:

13623532

Fusion Tag:

C-terminus V5 epitope tag

Promoter:

CMV

Titer:

1x1010~1x1011 PFU/ml

Storage Buffer:

DMEM with 2.5% BSA, 2.5% glycerol

Background:

DYRK2, or dual specificity tyrosine-phosphorylation-regulated kinase 2, has a role in the regulation of cellular growth and/or development. In response to DNA damage, DYRK2 regulates p53 phosphorylation on Ser-46 to induce apoptosis. DYRK2 has been proposed to inactivate GYS1 by phosphorylation at Ser-641, and potentially a second phosphorylation site, thus regulating glycogen synthesis. DYRK2 also phosphorylates EIF2B5 at Ser-544, enabling its subsequent phosphorylation and inhibition by GSK3, and may play a more general role in the priming of GSK3 substrates.

Documents:

Manual