Your shopping cart is empty!
| Description: | This recombinant human adenovirus type 5 (dE1/E3) expresses human coagulation factor III (F3) under CMV promoter. |
| Gene: | Coagulation Factor III (thromboplastin, Tissue Factor) |
| NCBI Acc. #: | NM_001993 |
| Gene ID: | 1272 |
| GI Number: | 1272 |
| Fusion Tag: | No |
| Promoter: | CMV |
| Titer: | 1x1010~1x1011 PFU/ml |
| Storage Buffer: | DMEM with 2.5% BSA, 2.5% glycerol |
| Background: | F3 gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants. |
| Documents: | Please contact us to request the manual |
