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Product Category:
Human Adenovirus Type5 (dE1/E3) expressing Glucagon-like Peptide 1 Receptor (GLP1R) under a CMV promoter.
Summary:
Glucagon-like Peptide 1 Receptor, premade adenovirus, ready to ship and ready to use format./td>
Gene Name:
Glucagon-like Peptide 1 Receptor
ACCN:
BC111843
Gene ID:
2740
GI Number:
109073256
Fusion Tag:
C-terminus V5 epitope tag
Promoter:
CWV
Titer:
1E+10~1E+11 PFU/ml
Storage Buffer:
DMEM with 2% BSA & 2.5% Glycerol
Background:
This gene encodes a 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. This receptor, which functions at the cell surface, becomes internalized in response to GLP-1 and GLP-1 analogs, and it plays an important role in the signaling cascades leading to insulin secretion. It also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated with diabetes. The protein is an important drug target for the treatment of type 2 diabetes and stroke. Alternative splicing of this gene results in multiple transcript variants.
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