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Product Category:
Human Adenovirus Type5 (dE1/E3) expressing Hepatocyte Growth Factor (hepapoietin A; Scatter Factor) (HGF).
Description:
Hepatocyte Growth Factor (hepapoietin A; Scatter Factor), pre-made adenovirus, ready to ship and ready to use format.
Gene Name:
Hepatocyte Growth Factor (hepapoietin A; Scatter Factor)
ACCN:
M73239
Gene ID:
3082
GI Number:
337935
Fusion Tag:
No
Promoter:
CMV
Titer:
1x1010~1x1011 PFU/ml
Storage Buffer:
DMEM with 2.5% BSA, 2.5% glycerol
Background:
Hepatocyte growth factor （HGF） regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule.
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