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Product Category:
Human Adenovirus Type5 (dE1/E3) expressing human Potassium Channel, Subfamily K, Member 18.
Description:
Pre-made adenovirus for over-expression of human Potassium Channel, Subfamily K, Member 18, ready to ship and ready to use format.
Gene Name:
Potassium Channel, Subfamily K, Member 18
ACCN:
NM_181840
Gene ID:
338567
GI Number:
338567
Fusion Tag:
No
Promoter:
CMV
Titer:
1x1010~1x1011 PFU/ml
Storage Buffer:
DMEM with 2.5% BSA, 2.5% glycerol
Background:
TRESK (TWIK-related spinal cord K+ channel) is a two-pore domain K+ channel that induces outward rectification and functions as a background K+ channel that is abundantly expressed in the spinal cord, thymus, spleen, and leukemic T-lymphocytes. TRESK is activated by increased cytoplasmic calcium concentration through calcineurin as well as by acetylcholine and histamine. It has been suggested that TRESK is linked to acute and chronic pain by activation of calcineurin. Other studies indicate that TRESK may play a role in the regulation of T-cell function and could be an excellent target to treat T-cell originated immune dysfunction.
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