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Product Category:
Human Adenovirus Type5 (dE1/E3) expressing Low Density Lipoprotein Receptor (familial Hypercholesterolemia) (LDLR).
Description:
Low Density Lipoprotein Receptor (familial Hypercholesterolemia), pre-made adenovirus, ready to ship and ready to use format.
Gene Name:
Low Density Lipoprotein Receptor (familial Hypercholesterolemia)
ACCN:
BC014514
Gene ID:
3949
GI Number:
3949
Fusion Tag:
No
Promoter:
CMV
Titer:
1x1010~1x1011 PFU/ml
Storage Buffer:
DMEM with 2.5% BSA, 2.5% glycerol
Background:
The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in the LDL-R gene cause the autosomal dominant disorder, familial hypercholesterolemia. Along with SCARB1, CLDN1, and the tetraspanin superfamily member CD81, LDL-R has been reported to be an entry factor for the Hepatitis C virus. At least three isoforms of LDL-R are known to exist.
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