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| Description: | Human Adenovirus Type5 (dE1/E3) expressing MAPK9 (kinase dead or dominant negative) under CMV promoter. |
| Gene: | Mitogen-activated Protein Kinase 9 (kinase dead or dominant negative) |
| Mutation: | K55M led to kinase dead or dominant negative |
| NCBI Acc. #: | NM_139069 |
| Gene ID: | 5601 |
| GI Number: | 21237741 |
| Fusion Tag: | No |
| Promoter: | CMV |
| Titer: | 1E+10~1E+11 PFU/ml |
| Storage Buffer: | DMEM with 2.5% BSA, 2.5% glycerol |
| Background: | The protein encoded by MAPK9 gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. |
| Documents: | Request a manual/MSDS |