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| Product Category: | Human Adenovirus Type5 (dE1/E3) expressing NGFI-A binding protein 2 (EGR1 binding protein 2) under CMV promoter. |
| Description: | NGFI-A binding protein 2 (EGR1 binding protein 2), pre-made adenovirus, ready to ship and ready to use format. |
| Gene: | NGFI-A binding protein 2 (EGR1 binding protein 2) |
| NCBI Acc. #: | BC065931.1 |
| Gene ID: | 4665 |
| GI Number: | 41946898 |
| Fusion Tag: | V5 epitope tag in C-terminal |
| Promoter: | CMV |
| Titer: | 1x1010~1x1011 PFU/ml |
| Storage Buffer: | DMEM with 2.5% BSA, 2.5% glycerol |
| Background: | Transcriptional control is in part regulated by interactions between DNA-bound transcription factors, such as Egr-1/NGFI-A, and coregulatory proteins, such as NAB (for NGFI-A-binding proteins). The evolutionarily conserved NAB proteins, NAB1 and NAB2, are corepressors of EGF-1/NGFI-A. Both NAB1 and NAB2 contain an amino terminal NAB conserved domain 1 (NCB1), which is required for binding NGFI-A, and a carboxy terminal NCD2 domain, which is responsible for the repressor function of NAB proteins. NAB2 is principally localized in the nucleus and may play a role in the downregulation of NGFI-A activity as well as in controlling fundamental processes such as cell division, differentiation and apoptosis. NAB2 has a predicted molecular mass of 56 kDa and localizes to chromosome 12q13.3-14.1, a region that is rearranged in several solid tumors, lipomas and liposarcomas. |
| Documents: | Please contact us to request the manual |
