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Product Category:
Human Adenovirus Type5 (dE1/E3) expressing Nuclear Receptor Subfamily 0, Group B, Member 2 (NR0B2).
Description:
Nuclear Receptor Subfamily 0, Group B, Member 2, pre-made adenovirus, ready to ship and ready to use format.
Gene Name:
Nuclear Receptor Subfamily 0, Group B, Member 2
ACCN:
NM_021969
Gene ID:
8431
GI Number:
8431
Fusion Tag:
C-terminus V5 epitope tag
Promoter:
CMV
Titer:
1x1010~1x1011 PFU/ml
Storage Buffer:
DMEM with 2.5% BSA, 2.5% glycerol
Background:
The protein encoded by NR0B2 gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function.
Documents:
