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Product Category:
Human Adenovirus Type5 (dE1/E3) expressing Nuclear Receptor Subfamily 1, Group H, Member 3 (NR1H3).
Description:
Nuclear Receptor Subfamily 1, Group H, Member 3, pre-made adenovirus, ready to ship and ready to use format.
Gene Name:
Nuclear Receptor Subfamily 1, Group H, Member 3
ACCN:
NM_005693
Gene ID:
10062
GI Number:
10062
Fusion Tag:
No
Promoter:
CMV
Titer:
1x1010~1x1011 PFU/ml
Storage Buffer:
DMEM with 2.5% BSA, 2.5% glycerol
Background:
NR1H3 (oxysterols receptor LXR-alpha) is a nuclear receptor that exhibits a ligand-dependent transcriptional activation activity. Its interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanucleotide half-sites spaced by four nucleotides. NR1H3 plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR, and LRP8. It also interplays functionally with RORA for the regulation of genes involves in liver metabolism.
Documents:
