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Product Category:
Human Adenovirus Type5 (dE1/E3) expressing Pim-1 Oncogene (PIM1) under a CMV promoter.
Description:
Pim-1 Oncogene (PIM1), pre-packaged adenovirus, ready to ship and ready to use format.
Gene Name:
Pim-1 Oncogene
ACCN:
NM_002648
Gene ID:
5292
GI Number:
4505810
Fusion Tag:
C-terminus V5 epitope tag
Promoter:
CMV
Titer:
1E+10~1E+11 PFU/ml
Storage Buffer:
DMEM with 2.5% BSA, 2.5% glycerol
Background:
The protein encoded by PIM1 gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810).
Documents:
