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Product Category:
Human Adenovirus Type5 (dE1/E3) expressing Survival Of Motor Neuron 1 under CMV promoter.
Description:
Survival Of Motor Neuron 1, pre-made adenovirus, ready to ship and ready to use format.
Gene Name:
Survival Of Motor Neuron 1, Telomeric
ACCN:
BC015308
Gene ID:
6606
GI Number:
15929773
Fusion Tag:
No; Co-expression with GFP
Promoter:
CMV
Titer:
1×1010~1×1011 PFU/ml
Storage Buffer:
DMEM with 2.5% BSA, 2.5% glycerol
Background:
The SMN1 gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. The telomeric and centromeric copies of this gene are nearly identical and encode the same protein - survival motor neuron protein. The SMN complex plays a catalyst role in the assemble of small nuclear ribonucleoproteins, the building blocks of the spliceosome. Mutations in the SMN1 gene are known to cause spinal muscular atrophy 1/2.
Storage:
-80°C
Documents:
