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Product Category:
Human Adenovirus Type5 (dE1/E3) expressing Sphingosine Kinase 1 under CMV promoter.
Description:
Sphingosine Kinase 1, premade adenovirus, ready to ship and ready to use format.
Gene Name:
Sphingosine Kinase 1
ACCN:
BC008040
Gene ID:
8877
GI Number:
14165485
Fusion Tag:
C-terminus 6xHN tag
Promoter:
CMV
Titer:
1E+10~1E+11 PFU/ml
Storage Buffer:
DMEM with 2.5% BSA, 2.5% glycerol
Background:
The protein encoded by SPHK1 gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Documents:
