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Product Category:
Human Adenovirus Type5 (dE1/E3) expressing Tripeptidyl Peptidase I (TPP1).
Description:
Tripeptidyl Peptidase I, pre-made adenovirus, ready to ship and ready to use format.
Gene Name:
Tripeptidyl Peptidase I
ACCN:
BC014863
Gene ID:
1200
GI Number:
15928807
Fusion Tag:
No
Promoter:
CMV
Titer:
1x1010~1x1011 PFU/ml
Storage Buffer:
DMEM with 2.5% BSA, 2.5% glycerol
Background:
The TPP1 gene encodes a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome.
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