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Product Category:
Human Adenovirus Type5 (dE1/E3) expressing Three Prime Repair Exonuclease 2 (TREX2).
Description:
Three Prime Repair Exonuclease 2, pre-made adenovirus, ready to ship and ready to use format.
Gene Name:
Three Prime Repair Exonuclease 2
ACCN:
BC008141
Gene ID:
11219
GI Number:
14198167
Fusion Tag:
No
Promoter:
CMV
Titer:
1x1011~1x1012 PFU/ml
Storage Buffer:
DMEM with 2.5% BSA, 2.5% glycerol
Background:
TREX2 is one of two major human 3' to 5' exonucleases which are required for checkpoint signaling after DNA damage. While the related protein TREX1 is required for ATR expression and mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, and Cree encephalitis, less is known about TREX2. Like TREX1, TREX2 is ubiquitously expressed in all tissues examined. X-ray crystallography studies of TREX2-single strand DNA complexes revealed that TREX2 binds DNA as a dimer and may act to displace the second DNA strand, suggesting that TREX2 unzips and denatures double stranded DNA and feed the substrate DNA strand into the TREX2 active site. At least two isoforms of TREX2 are known to exist.
Documents:
