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Product Category:
Human Adenovirus Type5 (dE1/E3) expressing ULK1.
Description:
Human Adenovirus Type5 (dE1/E3) expressing Human Unc-51-like Kinase 1 (C. Elegans) (ULK1).
Gene Name:
Unc-51-like Kinase 1 (C. Elegans)
ACCN:
BC111603
Gene ID:
8408
GI Number:
109939871
Fusion Tag:
No
Promoter:
CMV
Titer:
1E+10~1E+11 PFU/ml
Storage Buffer:
DMEM with 2.5% BSA, 2.5% glycerol
Background:
ULK1, also known as ATG1, is a key serine/threonine protein kinase probably acting at the most upstream step of autophagosome formation. Knockout of ULK1 results in a severe defect in the autophagy pathway. ULK1 is highly conserved among eukaryotes, and are the Unc-51-like kinases, ULK1 and ULK2 in mammals. ULK1 is ubiquitously expressed and involved in autophagy in response to starvation. It is the target of the TOR kinase signaling pathway that regulates autophagy through the control of phosphorylation status of ATG13. ULK1 also plays a role early in neuronal differentiation.
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