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Product Category:
Human Adenovirus Type5 (dE1/E3) expressing Fibroblast Growth Factor 2 (basic) (FGF2) under a CMV promoter.
Description:
Fibroblast Growth Factor 2 (basic), pre-made adenovirus, ready to ship and ready to use format.
Gene Name:
Fibroblast Growth Factor 2 (basic)
ACCN:
NM_002006.4
Gene ID:
2247
GI Number:
153285460
Fusion Tag:
No
Promoter:
CMV
Titer:
1x1010~1x1011 PFU/ml
Storage Buffer:
DMEM with 2.5% BSA, 2.5% glycerol
Background:
The protein encoded by bFGF gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF.
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