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Anti-Prickle Rabbit pAb (100 μl)
| Reactivity: | M,R & H,M |
| Applications: | WB & IHC |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Prickle rabbit polyclonal |
Gene Name: | Prickle-like protein 1 |
Synonyms: | EPM1B, prickle homolog 1 (Drosophila), Prickle like protein 1, PRICKLE1, RILP, REST-Interacting LIM Domain Protein |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse Prickle |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | |
Predicted MW. | 94 kDa |
Observed MW. | 55/94 kDa |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Mouse, Rat | 1: 500-1: 1000 | cerebral cortex, testis, cerebellum, brain |
IHC | Human, Mouse | 1: 1000-1: 2000 | placenta |
Background
This gene encodes a nuclear receptor that may be a negative regulator of the Wnt/beta-catenin signaling pathway. The encoded protein localizes to the nuclear membrane and has been implicated in the nuclear trafficking of the transcription repressors REST/NRSF and REST4. Mutations in this gene have been linked to progressive myoclonus epilepsy. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 3.
Images
 | Western blot analysis of Prickle (GB113285) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin-embedded human placenta using Prickle (GB113285) at dilution of 1: 2000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
