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Anti-ABHD6 Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | ABHD6 rabbit polyclonal antibody |
Gene Name: | Monoacylglycerol lipase ABHD6 |
Synonyms: | 2-arachidonoylglycerol hydrolase, Abhydrolase domain-containing protein 6, Abhd6 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse ABHD6 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 38 kDa |
Observed MW. | 38 kDa |
Uniprot ID: | Q8R2Y0, Q5XI64 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Mouse, Rat | 1: 500-1: 1000 | liver, brown fat, brain, small intestine |
Background
Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane. Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1-arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA). Also displays an ester hydrolase activity against acetyl ester, butanoate ester and hexadecanoate ester. Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2AG, an inhibitor of the sperm calcium channel CatSper, leading to calcium influx via CatSper and sperm activation . Involved in acrosomal reaction (Probable). May also play a role in smooth muscle cells migration .
Images
 | Western blot analysis of Abhd6 (GB112407) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
