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| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | ACTH rabbit polyclonal antibody |
Gene Name: | Pro-opiomelanocortin |
Synonyms: | POMC, ACTH, CLIP, LPH, MSH, NPP, POC, proopiomelanocortin, OBAIRH, Pomc |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse ACTH |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 27 kDa |
Observed MW. | 30 kDa |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Mouse, Rat | 1:250-1:500 | hypophysis, brain, cerebral cortex |
Background
Pro-opiomelanocortin (POMC) is a precursor polypeptide with 266 amino acid residues. POMC is synthesized in the pituitary from the 285-amino-acid-long polypeptide precursor pre-pro-opiomelanocortin (pre-POMC), by the removal of a 44-amino-acid-long signal peptide sequence during translation. POMC is cleaved to give rise to multiple peptide hormones(α-MSH, ACTH, β-Endorphin and [Met]enkephalin). Adrenocorticotropic hormone (ACTH, also adrenocorticotropin, corticotropin) is a polypeptide tropic hormone produced by and secreted by the anterior pituitary gland. It is also used as a medication and diagnostic agent.. ACTH is an important component of the hypothalamic-pituitary-adrenal axis and is often produced in response to biological stress. Its principal effects are increased production and release of cortisol by the cortex of the adrenal gland. ACTH is also related to the circadian rhythm in many organisms.
Images
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Western blot analysis of ACTH (GB11664) at dilution of 1: 250 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
