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Anti-ADAMTS1 Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | ADAMTS1 rabbit polyclonal antibody |
Gene Name: | A disintegrin and metalloproteinase with thrombospondin motifs 1 |
Synonyms: | ADAMTS1, ADAMTS, METH1. KIAA1346, A disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif 1, ADAM metallopeptidase with thrombospondin type 1 motif 1 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Human ADAMTS1 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 106 kDa |
Observed MW. | 110 kDa |
Uniprot ID: | P97857, Q9WUQ1 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Mouse, Rat | 1: 500-1: 1000 | heart, brain |
Background
ADAMTS1 (a disintegrin and metalloproteinase with thrombospondin motifs 1), is the founding member of the family of secreted zinc proteases with a multidomain structure. The protein precursor consists of a signal peptide and the following domains: pro, catalytic, disintegrinlike, TS type 1 motif, cysteine rich, spacer and a variable number of thrombospondin type 1 motifs. Based on their substrate specificity, ADAMTS1 and associated family members may be key enzymes in the degradation of cartilage leading to inflammation and arthritis. It is an active protease cleaving alpha 2 macroglobulin, aggrecan and versican. ADAMTS1 is essential for normal growth and the structure and function of the kidneys, adrenal glands and female reproductive organs. It also plays an important role in atherosclerosis.
Images
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Western blot analysis of ADAMTS1 (GB111011) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
