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Anti-AKR1C4 Rabbit pAb (100 μl)
| Reactivity: | H,M,R & H |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Aldo-keto reductase family 1 member C4 |
Synonyms: | 3 alpha HSD, 3 alpha HSD1, AKR1C4, C11, CDR, CHDR, Chlordecone reductase, DD 4, DD4 |
Immunogen: | Recombinant protein corresponding to Human AKR1C4 |
Uniprot ID: | P17516 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm |
Predicted MW. / Observed MW. | 37 kDa / 37 kDa |
Product Usage Information
WB | Human, Mouse, Rat | 1: 2000-1: 4000 | lung, liver |
IHC/IF | Human | 1: 500-1: 1000 | liver |
Background
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver.
Images
| Western blot analysis of AKR1C4 (GB114409) at dilution of 1: 2000 |
| Immunohistochemistry analysis of paraffin embedded human liver using AKR1C4 (GB114409) at dilution of 1: 500 |
| Immunofluorescence analysis of paraffin embedded human liver using AKR1C4 (GB114409) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
