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Anti-AMPK beta 1 Rabbit pAb (100 μl)
| Reactivity: | H,M,R & H,M,R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | 5'-AMP-activated protein kinase subunit beta-1 |
Synonyms: | AMPK subunit beta-1, AMPKb, Prkab1, AMPK, AMPK-BETA-1, HAMPKb, AMP-activated, noncatalytic, beta-1, AU021155 |
Immunogen: | Recombinant protein corresponding to Mouse AMPK beta 1 |
Uniprot ID: | Q9R078 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus, Cytoplasm |
Predicted MW. / Observed MW. | 30 kDa / 38 kDa |
Product Usage Information
WB | Human, Mouse, Rat | 1: 1000-1: 1500 | lung, colon |
IHC/IF | Human, Mouse, Rat | 1: 500-1: 1500 | colon |
Background
AMPK beta 1 is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol.
Images
| Western blot analysis of AMPKβ1 (GB111919) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin embedded mouse colon using AMPKβ1 (GB111919) at dilution of 1: 700 |
| Immunohistochemistry analysis of paraffin embedded rat colon using AMPKβ1 (GB111919) at dilution of 1: 700 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
