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Anti-AMPK beta 1 Rabbit pAb (100 μl)
| Reactivity: | H,M,R & H,M,R |
| Applications: | IHC & IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | AMPK beta 1 rabbit polyclonal |
Gene Name: | 5'-AMP-activated protein kinase subunit beta-1 |
Synonyms: | Prkab1, PRKAB1, AMPK, HAMPKb, Protein kinase AMP-activated non-catalytic subunit beta 1, AMPKβ1 |
Immunogen: | Recombinant protein corresponding to Mouse AMPKβ1 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm, Nucleus |
Uniprot ID: | Q9Y478, Q9R078, P80386 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Human, Mouse, Rat | 1: 500-1: 4000 | kidney cancer, brain |
IF | Human, Mouse, Rat | 1: 250-1: 500 | kidney cancer, brain |
Background
5'-AMP-activated protein kinase subunit beta-1 is an enzyme encoded by the PRKAB1 gene. The protein is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex.
Images
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Immunohistochemistry analysis of paraffin-embedded mouse tumor using AMPKβ1 (GB11899) at dilution of 1: 1000 |
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Immunohistochemistry analysis of paraffin-embedded mouse brain using AMPKβ1 (GB11899) at dilution of 1: 1000 |
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Immunohistochemistry analysis of paraffin-embedded rat brain using AMPKβ1 (GB11899) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
