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Anti-ARHGAP18 Rabbit pAb (100 μl)
| Reactivity: | H,M,R & M,R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | ARHGAP18 rabbit polyclonal antibody |
Gene Name: | Rho GTPase-activating protein 18 |
Synonyms: | Rho-type GTPase-activating protein 18, Arhgap18, MacGAP, SENEX |
Immunogen: | Recombinant protein corresponding to Mouse ARHGAP18 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm |
Predicted MW. | 75 kDa |
Observed MW. | 75 kDa |
Uniprot ID: | Q8N392, Q8K0Q5 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Human, Mouse, Rat | 1: 600-1: 1200 | liver |
IHC/IF | Mouse, Rat | 1: 700-1: 1400 | lung, small intestine, spleen |
Background
Rho GTPase activating protein that suppresses F-actin polymerization by inhibiting Rho. Rho GTPase activating proteins act by converting Rho-type GTPases to an inactive GDP-bound state. Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts downstream of YAP1 and inhibits actin polymerization, which in turn reduces nuclear localization of YAP1. Regulates cell shape, spreading, and migration.
Images
 | Western blot analysis of ARHGAP18 (GB112346) at dilution of 1: 600 |
 | Immunofluorescence of paraffin embedded mouse lung using ARHGAP18 (GB112346) at dilution of 1: 700 (450x lens) |
 | Immunofluorescence of paraffin embedded rat lung using ARHGAP18 (GB112346) at dilution of 1: 700 (400x lens) |
 | Immunofluorescence of paraffin embedded rat small intestine using ARHGAP18 (GB112346) at dilution of 1: 700 (450x lens) |
 | Immunofluorescence of paraffin embedded rat spleen using ARHGAP18 (GB112346) at dilution of 1: 700 (500x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
