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Anti-ARL6IP1 Rabbit pAb (100 μl)
| Reactivity: | H,M,R & M |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | ADP-ribosylation factor-like protein 6-interacting protein 1 |
Synonyms: | Aip 1, AIP1, ARL 6 interacting protein 1, ARL6IP, ARL6IP1, ARMER, KIAA0069 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse ARL6IP1 |
Uniprot ID: | Q9JKW0 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Endoplasmic reticulum |
Predicted MW. / Observed MW. | 23 kDa / 23 kDa |
Product Usage Information
WB | Human, Mouse, Rat | 1: 300-1: 600 | pancreas, testis |
IHC/IF | Mouse | 1: 300-1: 900 | lung, spleen, kidney |
Background
Positively regulates SLC1A1/EAAC1-mediated glutamate transport by increasing its affinity for glutamate in a PKC activity-dependent manner. Promotes the catalytic efficiency of SLC1A1/EAAC1 probably by reducing its interaction with ARL6IP5, a negative regulator of SLC1A1/EAAC1-mediated glutamate transport . Plays a role in the formation and stabilization of endoplasmic reticulum tubules. Negatively regulates apoptosis, possibly by modulating the activity of caspase-9 (CASP9). Inhibits cleavage of CASP9-dependent substrates and downstream markers of apoptosis but not CASP9 itself. May be involved in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation .
Images
| Western blot analysis of ARL6IP1 (GB114608) at dilution of 1: 600 |
| Immunohistochemistry of paraffin embedded mouse lung using ARL6IP1 (GB114608) at dilution of 1: 300 |
| Immunohistochemistry of paraffin embedded mouse spleen using ARL6IP1 (GB114608) at dilution of 1: 300 |
| Immunohistochemistry of paraffin embedded mouse kidney using ARL6IP1 (GB114608) at dilution of 1: 300 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
