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| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | ATG7 rabbit polyclonal |
Gene Name: | Ubiquitin-like modifier-activating enzyme ATG7 |
Synonyms: | ATG7, APG7-LIKE, APG7L, GSA7, autophagy related 7, hAGP7 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse ATG7 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | |
Uniprot ID: | Q9D906, O95352 |
Product Usage Information
IHC/IF | Mouse | 1: 600-1: 1200 | spleen, kidney |
Background
E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress. Plays also a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration, the maintenance of hematopoietic stem cells, the formation of Paneth cell granules, as well as in adipose differentiation.
Images
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Immunohistochemistry analysis of paraffin-embedded mouse spleen using ATG7 (GB11399) at dilution of 1:600. |
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Immunohistochemistry analysis of paraffin-embedded mouse spleen using ATG7 (GB11399) at dilution of 1:1200. |
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Immunohistochemistry analysis of paraffin-embedded mouse kidney using ATG7 (GB11399) at dilution of 1:600. |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
