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Anti-Alkaline Phosphatase Rabbit pAb (100 μl)
| Reactivity: | H & H |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Alkaline Phosphatase rabbit polyclonal |
Gene Name: | Alkaline phosphatase, tissue-nonspecific isozyme |
Synonyms: | ALPL, AP-TNAP, APTNAP, HOPS, TNAP, TNSALP, Alkaline phosphatase liver/bone/kidney, TNALP |
Immunogen: | Recombinant protein corresponding to Mouse Alkaline Phosphatase |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | membrane |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Mouse, Rat | 1: 200-1: 500 | bone |
IF | Mouse, Rat | 1: 200-1: 500 | bone |
Background
Intestinal, placental, placental-like, and liver/bone/kidney (tissue-nonspecific) all belong to alkaline phosphatases. the tissue-nonspecific form is located on chromosome 1. The product of this gene is a membrane-bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. This enzyme has been linked directly to hypophosphatasia disorder characterized by hypercalcemia and skeletal defects. Alkaline phosphatase allows for mineralization of calcium and phosphorus by bones and teeth. ALPL gene mutation leads to insufficient enzyme tissue-nonspecific alkaline phosphatase and allows for an accumulation of chemicals such as inorganic pyrophosphate to indirectly cause elevated calcium levels in the body and lack of bone calcification.
Images
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Immunohistochemistry analysis of paraffin-embedded mouse bone using Alkaline Phosphatase (GB11527) at dilution of 1: 400 |
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Immunohistochemistry analysis of paraffin-embedded mouse bone using Alkaline Phosphatase (GB11527) at dilution of 1: 400 |
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Immunohistochemistry analysis of paraffin-embedded rat bone using Alkaline Phosphatase (GB11527) at dilution of 1: 400 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
