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Anti-Amyloid beta precursor protein Rabbit pAb (100 μl)
| Reactivity: | M,R & M,R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Amyloid-beta precursor protein |
Synonyms: | ABPP, APP, Alzheimer disease amyloid A4 protein homolog, Amyloid precursor protein, AG, CVAP, PN-II, CTFgamma, AAA, ABETA, Cerebral vascular amyloid peptide, Beta-amyloid precursor protein |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse Amyloid Precursor Protein |
Uniprot ID: | P12023 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cell membrane, Nucleus, Secreted, Cytoplasm |
Predicted MW. / Observed MW. | 87 kDa / 100 kDa |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Mouse, Rat | 1: 500-1: 1000 | cerebellum, brain, hippocampus |
IHC/IF | Mouse, Rat | 1: 600-1: 1200 | cerebellum, substantia nigra |
Background
This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities.
Images
| Western blot analysis of APP (GB112075) at dilution of 1: 500 |
| Immunofluorescence of paraffin embedded mouse cerebellum using APP (GB112075) at dilution of 1: 600 (200x lens) |
| Immunofluorescence of paraffin embedded mouse substantia nigra using APP (GB112075) at dilution of 1: 600 (400x lens) |
| Immunofluorescence of paraffin embedded rat cerebellum using APP (GB112075) at dilution of 1: 600 (200x lens) |
| Immunofluorescence of paraffin embedded rat substantia nigra using APP (GB112075) at dilution of 1: 600 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
