Recombinant Anti-Androgen Receptor Rabbit mAb (50 μl)

Recombinant Anti-Androgen Receptor Rabbit mAb (50 μl)

Brand: ServiceBio
Cat. #: GB14170-50
Availability: In Stock
$259.00
-+
Reactivity: H,M,R    
Applications: IHC/IF    
Host Species: Rabbit    
Clonality: Monoclonal    
Gene Name:

Androgen receptor

Gene ID:

367

Immunogen:

KLH conjugated Synthetic peptide corresponding to Human Androgen Receptor

Uniprot ID:

P10275

Source:

Monoclonal, Rabbit IgG1, Kappa

Concentration:

1mg/ml

Purity:

Recombinant Expression and Affinity purified




Product Usage Information

IHC/IF

Human, Mouse, Rat

1:200-1:400

Prostate, testis




Background

The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoform




Images

01 20240423_YM7012_androgen receptor_ d200 mouse prostate_20x_IHC.png

Immunohistochemistry analysis of paraffin embedded  Mouse prostate using Androgen receptor (GB14170) at dilution of 1: 20

02 20240423_YM7012_androgen receptor_ d200 mouse testis_20x_IHC.png

Immunohistochemistry analysis of paraffin embedded  Mouse testis using Androgen receptor (GB14170) at dilution of 1: 20

03 20240423_YM7012_androgen receptor_ d200 rat testis_20x_IHC.png

Immunohistochemistry analysis of paraffin embedded  Rat testis using Androgen receptor (GB14170) at dilution of 1: 200

04 20240423_YM7012_androgen receptor_d200 rat prostate_20x_IHC.png

Immunohistochemistry analysis of paraffin embedded  Rat prostate using Androgen receptor (GB14170) at dilution of 1: 200




Storage

Storage Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA


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