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| Reactivity: | H |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Anaphase-promoting complex subunit 4 |
Synonyms: | ANAPC4, APC4, Cyclosome subunit 4 |
Immunogen: | Recombinant protein corresponding to Mouse ANAPC4 |
Uniprot ID: | Q91W96 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus |
Product Usage Information
IHC/IF | Human | 1: 500-1: 1000 | colon cancer, liver cancer, esophageal carcinoma |
Background
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).
Images
| Immunohistochemistry analysis of paraffin embedded human colon cancer using ANAPC4 (GB114438) at dilution of 1: 500 |
| Immunohistochemistry analysis of paraffin embedded human liver cancer using ANAPC4 (GB114438) at dilution of 1: 500 |
| Immunofluorescence analysis of paraffin embedded human esophageal carcinoma using ANAPC4 (GB114438) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
