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Anti-Asef2 Rabbit pAb (100 μl)
| Reactivity: | H |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Asef2 rabbit polyclonal antibody |
Gene Name: | Spermatogenesis-associated protein 13 |
Synonyms: | APC-stimulated guanine nucleotide exchange factor 2, Asef2, Spata13, RP11-307N16.3 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse Asef2 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 75 kDa |
Observed MW. | 75 kDa |
Uniprot ID: | Q96N96 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human | 1: 500-1: 1000 | HeLa, HepG2 |
Background
Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.
Images
| Western blot analysis of SPATA13 (GB111961) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
