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| Reactivity: | M |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | BAG2 rabbit polyclonal |
Gene Name: | BAG family molecular chaperone regulator 2 |
Synonyms: | BAG2, BAG-2, dJ417I1.2, BCL2 associated athanogene 2, Bag2 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse Bag2 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Rat | 1: 500-1: 1000 | spleen, lymph node |
IF | Rat | 1: 500-1: 1000 | spleen, lymph node |
Background
BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner.
Images
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Immunohistochemistry analysis of paraffin-embedded rat lymph node using Bag2 (GB11378) at dilution of 1: 1000 |
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Immunohistochemistry analysis of paraffin-embedded rat spleen using Bag2 (GB11378) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
