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Anti-BLOC1S1 Rabbit pAb (100 μl)
| Reactivity: | R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Biogenesis of lysosome-related organelles complex 1 subunit 1 |
Synonyms: | BLOC 1 subunit 1, BLOS1, GCN5 like protein 1, GCN5L1, MICoA, Protein RT14, RT14 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse BLOC1S1 |
Uniprot ID: | O55102 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 14 kDa / 17 kDa |
Product Usage Information
WB | Rat | 1: 500-1: 1000 | brain, skeletal musde |
Background
Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. The BORC complex is most probably associated with the cytosolic face of lysosomes, may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (By similarity).; May negatively regulate aerobic respiration through mitochondrial protein lysine-acetylation. May counteract the action of the deacetylase SIRT3 by acetylating and regulating proteins of the mitochondrial respiratory chain including ATP5F1A and NDUFA9.
Images
| Western blot analysis of BLOC1S1 (GB115409) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
