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Anti-BNIP3 Rabbit pAb (100 μl)
| Reactivity: | H,M |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | BNIP3 rabbit polyclonal antibody |
Gene Name: | BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 |
Synonyms: | Bnip3, Nip3 |
Immunogen: | Recombinant protein corresponding to Mouse BNIP3 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm |
Uniprot ID: | Q12983, O55003 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Human, Mouse | 1: 1000-1: 2000 | breast cancer, colon cancer, spleen, testis |
Background
The BNIP3 is an apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway.
Images
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Immunohistochemistry of paraffin embedded human breast cancer using BNIP3 (GB111204) at dilution of 1:1000 (400x lens) |
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Immunohistochemistry of paraffin embedded human colon cancer using BNIP3 (GB111204) at dilution of 1:1000 (400x lens) |
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Immunohistochemistry of paraffin embedded mouse spleen using BNIP3 (GB111204) at dilution of 1:1000 (400x lens) |
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Immunohistochemistry of paraffin embedded mouse testis using BNIP3 (GB111204) at dilution of 1:1000 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
