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| Reactivity: | H,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | BRCA2 rabbit polyclonal antibody |
Gene Name: | Breast cancer type 2 susceptibility protein homolog |
Synonyms: | Brca2, BRCA2, BRCC2, BROVCA2, FACD, FAD, FAD1, FANCD, FANCD1, GLM3, PNCA2, XRCC11, Breast cancer 2, DNA repair associated, breast cancer 2, Early onset, BRCA2 DNA repair associated |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse BRCA2 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm, Nucleus |
Uniprot ID: | P51587 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Human, Rat | 1: 500-1: 2000 | brain, tumor |
Background
Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures.
Images
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Immunohistochemistry of paraffin embedded rat tumor using BRCA2 (GB11918) at dilution of 1:2000 (200x lens) |
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Immunohistochemistry of paraffin embedded rat tumor using BRCA2 (GB11918) at dilution of 1:1000 (250x lens) |
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Immunofluorescence of paraffin embedded rat brain using BRCA2 (GB11918) at dilution of 1:1000 (250x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
